Dominic Cosgrove Selected Research

Hereditary Nephritis (Alport Syndrome)

1/2022	Molecular and Cellular Mechanisms Underlying the Initiation and Progression of Alport Glomerular Pathology.
1/2017	Collagen IV diseases: A focus on the glomerular basement membrane in Alport syndrome.
11/2016	Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice.
1/2016	X-Linked Alport Dogs Demonstrate Mesangial Filopodial Invasion of the Capillary Tuft as an Early Event in Glomerular Damage.
10/2013	α1β1 integrin/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome.
6/2012	Glomerular pathology in Alport syndrome: a molecular perspective.
11/2010	Collagen XIII induced in vascular endothelium mediates alpha1beta1 integrin-dependent transmigration of monocytes in renal fibrosis.
11/2009	Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease.
3/2009	Stem cell therapy for Alport syndrome: the hope beyond the hype.
3/2008	Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome.

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Dominic Cosgrove Research Topics

Disease

16	Hereditary Nephritis (Alport Syndrome) 01/2022 - 05/2003
8	Fibrosis (Cirrhosis) 01/2018 - 04/2003
7	Proteinuria 01/2016 - 04/2003
6	Usher Syndromes (Usher Syndrome) 01/2014 - 01/2002
4	Kidney Diseases (Kidney Disease) 05/2006 - 08/2002
3	Hypoxia (Hypoxemia) 01/2020 - 10/2005
3	Hypertension (High Blood Pressure) 01/2016 - 11/2009
3	Neoplasms (Cancer) 08/2007 - 04/2003
3	type 2A Usher syndrome 08/2005 - 01/2004
2	Glomerulonephritis 01/2022 - 10/2013
2	Hearing Loss (Hearing Impairment) 11/2016 - 10/2013
2	Blindness (Hysterical Blindness) 01/2014 - 01/2014
2	Deafness (Deaf Mutism) 01/2014 - 04/2006
2	Deaf-Blind Disorders 01/2014 - 01/2004
2	Renal Insufficiency (Renal Failure) 11/2009 - 05/2006
2	Disease Progression 03/2008 - 04/2006
1	Sclerosis 01/2018
1	Albuminuria 01/2018
1	Azotemia 01/2016
1	type 1B Usher syndrome 01/2014
1	Retinal Degeneration 10/2008
1	Pathologic Processes 06/2005
1	Sensorineural Hearing Loss 05/2005
1	Inborn Genetic Diseases (Disease, Hereditary) 05/2003
1	Cicatrix (Scar) 05/2003
1	Pre-Eclampsia (Preeclampsia) 04/2003
1	Hypertrophy 04/2003
1	Atrophy 04/2003

Drug/Important Bio-Agent (IBA)

11	Collagen Type IV (Type IV Collagen)IBA 01/2017 - 05/2003
8	CollagenIBA 01/2022 - 05/2003
8	Matrix Metalloproteinases (MMPs)IBA 11/2009 - 04/2003
6	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2002
4	IntegrinsIBA 01/2016 - 10/2005
3	Integrin alpha1beta1IBA 11/2010 - 08/2004
2	NitrogenIBA 01/2018 - 01/2014
2	Urea (Carbamide)FDA LinkGeneric 01/2018 - 01/2014
2	Messenger RNA (mRNA)IBA 01/2018 - 04/2003
2	Metalloproteases (Metalloproteinases)IBA 01/2016 - 04/2003
2	CytokinesIBA 01/2016 - 11/2009
2	Retinaldehyde (Retinal)IBA 01/2014 - 01/2014
2	Myosin VIIaIBA 01/2014 - 08/2011
2	NG-Nitroarginine Methyl Ester (L-NAME)IBA 10/2013 - 11/2009
2	AntibodiesIBA 11/2010 - 04/2003
2	GelatinasesIBA 03/2008 - 05/2003
2	Integrin alpha1IBA 03/2008 - 10/2005
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2005 - 04/2003
2	Peptides (Polypeptides)IBA 08/2005 - 01/2004
1	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2018
1	Fibronectins (Fibronectin)IBA 01/2016
1	Laminin (Merosin)IBA 01/2016
1	Endothelin-1 (Endothelin 1)IBA 01/2016
1	Retinal Pigments (Pigments, Visual)IBA 01/2014
1	Protein Isoforms (Isoforms)IBA 01/2014
1	TAE226IBA 01/2014
1	Cadherins (E-Cadherin)IBA 01/2014
1	SaltsIBA 10/2013
1	Interleukin-6 (Interleukin 6)IBA 11/2009
1	Nitric Oxide Synthase (NO Synthase)IBA 11/2009
1	TetraspaninsIBA 09/2009
1	p38 Mitogen-Activated Protein KinasesIBA 03/2008
1	Integrin alpha3beta1IBA 08/2007
1	Integrin beta3 (GPIIIa)IBA 08/2007
1	Integrin alpha3IBA 08/2007
1	Matrix Metalloproteinase 12IBA 07/2006
1	type IV collagen alpha3 chain (Goodpasture antigen)IBA 05/2006
1	Matrix Metalloproteinase InhibitorsIBA 04/2006
1	Biological ProductsIBA 06/2005
1	Coloring Agents (Dyes)IBA 07/2004
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 07/2004
1	RNA (Ribonucleic Acid)IBA 07/2004
1	Collagenases (Collagenase)FDA Link 05/2003
1	Matrix Metalloproteinase 14 (MT1-MMP)IBA 05/2003
1	nephrinIBA 04/2003
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 04/2003
1	Neutralizing AntibodiesIBA 04/2003
1	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 04/2003
1	GelatinIBA 04/2003
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 04/2003
1	Uridine Triphosphate (UTP)IBA 04/2003
1	Blood Proteins (Serum Proteins)IBA 08/2002
1	Cell Surface ReceptorsIBA 01/2002

Therapy/Procedure

2	Therapeutics 03/2009 - 04/2003
1	Euthanasia (Mercy Killing) 01/2016
1	Transplantation 05/2006